Salinomycin kills cancer stem cells in different types of human cancers by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, mitochondrial function and other cancer stem cell (CSC) pathways. 90, 91 By comparing the chemical structures and cellular effects of this drug with those of valinomycin (K + ionophore) and nigericin (K + /H + exchanger), these authors concluded that salinomycin mediates K + /H + exchange across the inner mitochondrial membrane.

The colorectal cancer SW480 and HT29 cells were incubated with salinomycin at 0.5 and 1.0 μM for 1 week, and sphere formation was markedly inhibited after treatment with salinomycin (Figure 6a,b). The expression of stemness marker genes, LGR5, CD44, and Sox2, was then examined by real‐time PCR.

However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1 Abstract Since Salinomycin (Sal) emerged its ability to target breast cancer stem cells in 2009, numerous experiments have been carried out to test Sal’s anticancer effects. What deserve to be mentioned is that Sal can efficiently induce proliferation inhibition, cell death and metastasis suppression against human cancers from different origins both in vivo and in vitro without causing Salinomycin, the first ranked drug, has recently been considered as a promising novel anti-cancer agent for targeting human cancer stem cells despite its not well-known mechanism of action (32)(33 2012-09-19 · Background Salinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell death in human cancer cells displaying multiple mechanisms of drug resistance. The underlying mechanisms leading to cell death after salinomycin treatment have not been well characterized. We therefore investigated the role of salinomycin in caspase dependent and independent cell death in Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin has been shown by Piyush Gupta et al.

Salinomycin may inhibit the cancer stem-like populations with increased chemoradioresistance that nasopharyngeal cancer tumorspheres contain Gong Zhang , Shuping Zhang , Jinjin Ren , Chunxiao Yao , Zhongren Zhao , Xiurong Qi , Xiaofeng Zhang , Shuye Wang , and Lei Li In conclusion, the individual use of salinomycin and combined use with 17‑AAG may significantly inhibit SGC‑7901 gastric cancer cell proliferation and induce cell apoptosis. The potential mechanisms may be associated with upregulation of Fas‑L and downregulation of NF‑κB. 2017-05-16 · Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal properties and the capacity to seed tumours. CSCs are typically refractory to conventional treatments 2009-08-21 · Viable cancer cells in tumors from salinomycin-treated mice were mostly restricted to the periphery of the tumor mass (Figure 5D). E-cadherin protein, which is not normally expressed in the SUM159 line, was focally expressed specifically in tumors from salinomycin-treated mice and not in tumors from control vehicle-treated mice ( Figure 5 D). Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis.

Synopsis An active fluorescent salinomycin conjugate reveals rapid cellular The subcellular localization of salinomycin conjugates in breast cancer cells was

2019-11-13 · Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma Abstract. Uveal melanoma (UM) is the most common primary intraocular tumor.

Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis‐resistant cancer cells may define salinomycin as a novel anticancer drug.

Cancer stems cells (CSCs) are a subpopulation of Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti- cancer properties. It induces cell death in some types of cancer cells such as breast, “To investigate its action, we developed a surrogate salinomycin drug, ironomycin, that was at least 10-fold more potent than salinomycin against CSCs in vitro and Salinomycin is promising primarily because it has been shown to kill the cancer stem cells while at the same time enabling other drugs to more efficiently kill the Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2,9 via AMPK-SIRT1 pathway in a non-small cell lung cancer. Hak-Ryul Kim, Jae-Sam View all Antibiotics products.

These effects are associated with expressional down-regulation of superoxide dismutase-1 (SOD1) in response to salinomycin treatment. 2019-11-13 · Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma Abstract. Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct Background. Uveal melanoma (UM) is the most common primary intraocular Salinomycin was originally used as an anticoccidial drug in poultry, and for efﬁcient nutrient absorption in piggery. Its preferential toxicity towards cancer-stem cells was described by Gupta and colleagues in the end of the last decade [1].
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It is a very fast-growing cancer that spreads quickly. Glioblastoma is the most common type of malignant brain tumor in adults.
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2012-09-19 · Background Salinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell death in human cancer cells displaying multiple mechanisms of drug resistance. The underlying mechanisms leading to cell death after salinomycin treatment have not been well characterized. We therefore investigated the role of salinomycin in caspase dependent and independent cell death in

Salinomycin seems to work well when combined with Chemo (such as Cisplatin, Gemcitabine, Erlotinib and at least a few 3. The Chemo Salinomycin reduces epithelial-mesenchymal transition-mediated multidrug resistance by modifying long noncoding RNA HOTTIP expression in gastric cancer cells Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma Abstract.

Salinomycin activates an unconventional pathway of apoptosis in human cancer cells that may contribute to the breakdown of apoptosis resistance. The ability of salinomycin to effectively kill both cancer stem cells and apoptosis-resistant cancer cells may define the compound as a novel and effective anticancer agent.

E-cadherin protein, which is not normally expressed in the SUM159 line, was focally expressed specifically in tumors from salinomycin-treated mice and not in tumors from control vehicle-treated mice ( Figure 5 D). Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis. 2018-12-25 · Salinomycin is a monocarboxylic polyether antibiotic, which has been proved to possess anti-tumor activities in multiple types of cancer cells. However, its effects on RCC cells remains unclear. In our study, salinomycin could inhibit the proliferation and viability of RCC cell lines 786-O and ACHN. 2021-02-01 · Cancer researches on salinomycin all attributes the antitumor effects to its specific activity on cancer stem cells (CSCs), overlooking the fundamental roles of macrophage played in tumor metastasis.

Genes Chromosomes and Cancer, 1993 (7) 231-239. 7) SV Allander, S. Bajalica, salinomycin on cancer cell lines and cancer stem cells. Oncotarget 2016 I vårt samarbete testar vi dessa olika varianter av salinomycin och samtidigt lär vi oss mer om cancerstamceller. Nya rön i Bolivia och Alnarp I sin forskning har Salinomycin har visat sig kontrollera stamceller från bröstcancer, även om mekanismerna som ligger till grund för dess cancer mot cancer är inte tydliga. Salinomycin Treatment Specifically Inhibits Cell Proliferation of Cancer Stem single cell tracking; cancer stem cells; salinomycin; JIMT-1 breast cancer cells av L Lin · 2014 · Citerat av 24 — Keywords: Cervical cancer, Wnt5A, Wnt/Ca2+ signaling, prognosis Lu W, Li Y. Salinomycin suppresses LRP6 expression and inhibits both BioMed Central Ltd. Background: Cancer stem cells CSCs have been of salinomycin, previously shown to exhibit increased activity against cancer cells, also The cancer stem cell CSC hypothesis provides an attractive cellular mechanism to account for Salinomycin as a drug for targeting human cancer stem cells.